チエルノフ　ミハイル    Department   School of Medicine(Tokyo Women's Medical University Adachi Medical Center), School of Medicine    Position   Assistant Professor
Article types	Original article
Language	English
Peer review	Peer reviewed
Title	Coincidence of central neurocytoma and multiple glioblastomas:a rare cace report
Journal	Formal name：J Neurooncol ISSN code：1573-7373
Volume, Issue, Page	93(3),pp.431-435
Author and coauthor	MURAGAKI Yoshihiro†, CHERNOV Mikhail, Tajika Yasuhiko Tajika Yasuhiko, KUBO Osami, ISEKI Hiroshi, HORI Tomokatsu
Publication date	2009/07
Summary	Epub 2009 Jan 29. Coincidence of parenchymal primary brain tumors of different histogenesis is extremely rare. To the best of our knowledge, the present case of simultaneous appearance of a central neurocytoma and multiple glioblastomas is the first to be reported. Multiple intraaxial brain neoplasms were disclosed in a 39-year-old man and were surgically resected. Histological diagnosis of the tumor located in the right lateral ventricle was central neurocytoma whereas two tumors of the left temporal lobe were glioblastomas. The latter were located in close proximity to the subarachnoid space, had atypical radiological appearance, and were slightly positive for synaptophysin and neurofilament protein. It can be speculated that both malignant neoplasms were, in fact, dedifferentiated central neurocytoma, which developed from distant tumor deposits. This case seems to be in agreement with the hypothesis that central neurocytoma arises from the progenitor cells with potential for both neuronal and glial differentiation. Better understanding of histogenesis of this tumor is definitely neede
DOI	10.1007/s11060-008-9793-0
PMID	19183852