八巻　隆    Department   School of Medicine(Tokyo Women's Medical University Adachi Medical Center), School of Medicine    Position   Professor
Article types	Original article
Language	English
Peer review	Peer reviewed
Title	Treatment of facial angiofibroma of tuberous sclerosis using cultured epithelial autografts.
Journal	Formal name：Annals of plastic surgery Abbreviation：Ann Plast Surg ISSN code：0148-7043(Print)0148-7043(Linking)
Volume, Issue, Page	57(4),pp.415-7
Author and coauthor	Hori Keijiro†, Soejima Kazutaka, Nozaki Motohiro, Sakurai Hiroyuki, Takeuchi Masaki, Yamaki Takashi, Iwasaka Susumu, Kono Taro, Honda Takashi, Isago Tsukasa
Publication date	2006/10
Summary	Treatment of facial angiofibroma of tuberous sclerosis is problematic, because the skin lesions involve entire dermis. Five patients aged from 14 to 33 (mean: 23.6) years old with angiofibroma of tuberous sclerosis were treated with cultured epithelial autografts between 1995 and 2004. The entire area of the facial lesions was excised using a razor to remove large nodules, and then the remaining lesions were further abraded to a rather deep layer of the dermis to smooth the skin and remove small nodules. Then a cultured autologous epithelium was grafted onto the wound. In all patients, epithelization was complete within 10 (mean: 9) days after the surgery. All patients were followed up for more than 6 months and showed neither depigmentation due to scar formation nor hypertrophic scars. In some patients, some pebbly regrowth had occurred at 5 years postoperatively, but the appearance was quite acceptable.
DOI	10.1097/01.sap.0000221621.34715.21
Document No.	16998334