KATSURA Hideki    Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine    Position   Professor
Article types	Case report
Language	English
Peer review	Peer reviewed
Title	EGFR mutation of adenocarcinoma in congenital cystic adenomatoid malformation/congenital pulmonary airway malformation: a case report.
Journal	Formal name：Japanese journal of clinical oncology Abbreviation：Jpn J Clin Oncol ISSN code：(1465-3621)0368-2811(Linking)
Volume, Issue, Page	44(3),pp.278-81
Author and coauthor	Hasegawa Mizue†*, Sakai Fumikazu, Arimura Ken, Katsura Hideki, Koh Eitetsu, Sekine Yasuo, Hiroshima Kenzo
Publication date	2014/03
Summary	An 80-year-old man underwent right upper lobectomy for the resection of multiple cysts accompanied by a nodule. The pathological diagnosis was adenocarcinoma with surrounding atypical epithelial cell proliferation in a Type 1 congenital cystic adenomatoid malformation/congenital pulmonary airway malformation. There was epidermal growth factor receptor mutation in the adenocarcinoma and surrounding atypical epithelial cells that had proliferated. Malignant transformation of congenital cystic adenomatoid malformation/congenital pulmonary airway malformation may be related to the epidermal growth factor receptor pathway in this case, with atypical epithelial cell proliferation as a precursor. We emphasize the importance of complete resection of congenital cystic adenomatoid malformation/congenital pulmonary airway malformation and the possibility of treatment with epidermal growth factor receptor tyrosine kinase inhibitors in epidermal growth factor receptor-mutated cases.
DOI	10.1093/jjco/hyt226
PMID	24482415