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ヤマザキ ケンジ
KENJI YAMAZAKI
山崎 健二 所属 医学部 医学科（東京女子医科大学病院） 職種 客員教授 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Left heart pressures can be the key to know the limitation of left ventricular assist device support against progression of aortic insufficiency. |
| 掲載誌名 | 正式名：Journal of Artificial Organs 略 称：J Artif Organs ISSNコード：1434-7229/1619-0904 |
| 掲載区分 | 国内 |
| 出版社 | The Japanese Society for Artificial Organs |
| 巻・号・頁 | 21(3),pp.265-270 |
| 著者・共著者 | IIZUKA Kei†, NISHINAKA Tomohiro, NAITO Noritsugu, AKIYAMA Daichi, TAKEWA Yoshiaki, YAMAZAKI Kenji, TATSUMI Eisuke |
| 発行年月 | 2018/07 |
| 概要 | Aortic insufficiency (AI) is a worrisome complication under left ventricular assist device (LVAD) support. AI progression causes LVAD-left ventricular (LV) recirculation and can require surgical intervention to the aortic valve. However, the limitations of LVAD support are not well known. Using an animal model of LVAD with AI, the effect of AI progression on hemodynamics and myocardial oxygen metabolism were investigated. Five goats (Saanen 48 ± 2 kg) underwent centrifugal type LVAD, EVAHEART, implantation. The AI model was established by placing a vena cava filter in the aortic valve. Cardiac dysfunction was induced by continuous beta-blockade (esmolol) infusion. Hemodynamic values and myocardial oxygen extraction ratio (O2ER) were evaluated while changing the degree of AI which was expressed as the flow rate of LVAD-LV recirculation (recirculation rate). Diastolic aortic pressure was decreased with AI progression and correlated negatively with the recirculation rate (p = 0.00055). Systolic left ventricular pressure (LVP) and mean left atrial pressure (LAP) were increased with AI progression and correlated positively with the recirculation rate (p = 0.010, 0.023, respectively). LVP and LAP showed marked exponential increases when the recirculation rate surpassed 40%. O2ER was also increased with AI progression and had a significant positive correlation with the recirculation rate (p = 0.000043). O2ER was increased linearly, with no exponential increase. AI progression made it difficult to reduce the cardiac pressure load, worsening myocardial oxygen metabolism. The exponential increase of left heart pressures could be the key to know the limitation of LVAD support against AI progression. |
| DOI | 10.1007/s10047-018-1027-4 |
| PMID | 29464441 |