上芝　秀博    Department   School of Medicine, School of Medicine    Position   Assistant Professor
Article types	Original article
Language	English
Peer review	Peer reviewed
Title	Analysis of the superantigen-producing ability of Yersinia pseudotuberculosis strains of various serotypes isolated from patients with systemic or gastroenteric infections, wildlife animals and natural environments.
Journal	Formal name：Zentralblatt fur Bakteriologie : international journal of medical microbiology Abbreviation：Zentralbl Bakteriol ISSN code：09348840/09348840
Domestic / Foregin	Foregin
Volume, Issue, Page	288(2),pp.277-91
Author and coauthor	Ueshiba H, Kato H, Miyoshi-Akiyama T, Tsubokura M, Nagano T, Kaneko S, Uchiyama T
Authorship	Lead author
Publication date	1998/10
Summary	Yersinia pseudotuberculosis is a pathogen causing gastroenteritis as well as acute and systemic infections. This organism produces a superantigenic exotoxin, designated Y. pseudotuberculosis-derived mitogen (YPM). We consider this exotoxin to be the primary pathogen of the systemic type infection. In this study, we examined 101 Y. pseudotuberculosis strains isolated from various sources, patients with the systemic or the gastroenteric type of infections, wildlife animals and natural environments for the presence of the YPM gene and the production of YPM or other related superantigens. We found that all of the strains isolated from patients with systemic type infection carried the YPM gene and produced YPM. A certain proportion of the organisms isolated from patients with the gastroenteric type infection, wildlife animals or natural environments did not carry the YPM gene nor produced superantigens. These results suggest that YPM is involved in the pathogenesis of the systemic type of Y. pseudotuberculosis infection.
DOI	10.1016/s0934-8840(98)80051-0
PMID	9809408