UESHIBA Hidehiro
   Department   School of Medicine, School of Medicine
   Position   Assistant Professor
Article types Original article
Language English
Peer review Peer reviewed
Title Analysis of the superantigen-producing ability of Yersinia pseudotuberculosis strains of various serotypes isolated from patients with systemic or gastroenteric infections, wildlife animals and natural environments.
Journal Formal name:Zentralblatt fur Bakteriologie : international journal of medical microbiology
Abbreviation:Zentralbl Bakteriol
ISSN code:09348840/09348840
Domestic / ForeginForegin
Volume, Issue, Page 288(2),pp.277-91
Author and coauthor Ueshiba H, Kato H, Miyoshi-Akiyama T, Tsubokura M, Nagano T, Kaneko S, Uchiyama T
Authorship Lead author
Publication date 1998/10
Summary Yersinia pseudotuberculosis is a pathogen causing gastroenteritis as well as acute and systemic infections. This organism produces a superantigenic exotoxin, designated Y. pseudotuberculosis-derived mitogen (YPM). We consider this exotoxin to be the primary pathogen of the systemic type infection. In this study, we examined 101 Y. pseudotuberculosis strains isolated from various sources, patients with the systemic or the gastroenteric type of infections, wildlife animals and natural environments for the presence of the YPM gene and the production of YPM or other related superantigens. We found that all of the strains isolated from patients with systemic type infection carried the YPM gene and produced YPM. A certain proportion of the organisms isolated from patients with the gastroenteric type infection, wildlife animals or natural environments did not carry the YPM gene nor produced superantigens. These results suggest that YPM is involved in the pathogenesis of the systemic type of Y. pseudotuberculosis infection.
DOI 10.1016/s0934-8840(98)80051-0
PMID 9809408