HASHIMOTO Yasunobu
Department School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine Position Assistant Professor |
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Article types | Original article |
Language | English |
Peer review | Peer reviewed |
Title | Prognostic impact of sarcopenia in patients with metastatic hormone-sensitive prostate cancer. |
Journal | Formal name:Japanese journal of clinical oncology Abbreviation:Jpn J Clin Oncol ISSN code:14653621/03682811 |
Domestic / Foregin | Foregin |
Volume, Issue, Page | 50(8),pp.933-939 |
Author and coauthor | IKEDA Takashi†, ISHIHARA Hiroki, IIZUKA Junpei*, HASHIMOTO Yasunobu, YOSHIDA Kazuhiko, KAKUTA Yoichi, TAKAGI Toshio, OKUMI Masayoshi, ISHIDA Hideki, KONDO Tsunenori, TANABE KAZUNARI* |
Publication date | 2020/08 |
Summary | BACKGROUND:Cancer cachexia is associated with a poor prognosis. This study aimed to investigate the association between sarcopenia and survival in patients with metastatic hormone-sensitive prostate cancer.RESULTS:In total, 163 patients (82.7%) had sarcopenia. Cancer-specific survival and overall survival were significantly shorter in sarcopenic patients than in non-sarcopenic patients (median cancer-specific survival: 77.0 months vs. not reached, P = 0.0099; overall survival: 72.0 months vs. not reached, P = 0.0465), whereas castration-resistance prostate cancer-free survival did not significantly differ between the groups (P = 0.6063). Multivariate analyses showed that sarcopenia was an independent factor for cancer-specific survival (hazard ratio: 2.18, P = 0.0451), together with the Gleason score (hazard ratio: 1.87, P = 0.0272) and LATITUDE risk classification (hazard ratio: 2.73, P = 0.0008). Moreover, the prognostic association of sarcopenia was remarkable in patients aged <73.0 years (cancer-specific survival: 82.0 months vs. not reached, P = 0.0027; overall survival: 72.0 months vs. not reached, P = 0.0078 in sarcopenic vs. non-sarcopenic patients), whereas the association was not significant in patients aged ≥73.0 years (cancer-specific survival: 76.0 and 75.0 months, respectively, P = 0.7879; overall survival: 67.0 and 52.0 months, respec |
DOI | 10.1093/jjco/hyaa045 |
PMID | 32303747 |