オガワ テツヤ   OGAWA Tetsuya
  小川 哲也
   所属   医学部 医学科(東医療センター)
   職種   教授
論文種別 原著
言語種別 英語
査読の有無 査読あり
表題 Left ventricular end-diastolic diameter is an independent predictor of mortality in hemodialysis patients.
掲載誌名 正式名:Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy
略  称:Ther Apher Dial
ISSNコード:1744-9987(Electronic)1744-9979(Linking)
巻・号・頁 16(2),134-41頁
著者・共著者 Inoue Tomoko†, Ogawa Tetsuya, Iwabuchi Yuko, Otsuka Kuniaki, Nitta Kosaku
発行年月 2012/04
概要 Left ventricular (LV) function is impaired in most hemodialysis (HD) patients. We conducted an observational cohort study to investigate whether LV end-diastolic diameter (LVDd) could predict all-cause mortality in a cohort of 166 HD patients. The LVDd values (5.06 ± 0.64 cm) of the non-survivor group were significantly greater than in the survivor group (4.78 ± 0.71 cm). The area under the receiver operating characteristic curve for an LVDd cut-off value of 5.01 cm was 0.6145 (P = 0.0234).The sensitivity and specificity of the LVDd threshold of 5.01 cm were 75.7% and 50.4%, respectively. The 4-year survival rate was significantly lower in the group with LVDd ≥ 5.01 cm than in the group with LVDd<5.01 cm (log-rank test, P = 0.0047). Multivariate analysis with adjustments for clinical and echocardiographic parameters showed that increased LVDd was an independent predictor of all-cause mortality (hazard ratio 2.363, 95% CI 1.320-4.228, P = 0.0013). The results of the present study showed that increased LVDd predicts the all-cause mortality of chronic HD patients better than other echocardiographic parameters. Our findings suggest that LVDd measurements may be helpful for risk stratification and providing therapeutic direction for the management of HD patients.
DOI 10.1111/j.1744-9987.2011.01048.x
文献番号 22458391