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SUTO Chikako
Department School of Medicine(Tokyo Women's Medical University Adachi Medical Center), School of Medicine Position Professor |
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| Article types | Original article |
| Language | English |
| Peer review | Non peer reviewed |
| Title | Efficacy of retinol palmitate eye drops for dry eye in rabbits with lacrimal gland resection. |
| Journal | Formal name：Clinical ophthalmology (Auckland, N.Z.) Abbreviation：Clin Ophthalmol ISSN code：11775483/11775467 |
| Volume, Issue, Page | 6,pp.1585-1593 |
| Author and coauthor | Odaka Akito†, Toshida Hiroshi, Ohta Toshihiko, Tabuchi Nobuhito, Koike Daisuke, Suto Chikako, Murakami Akira |
| Publication date | 2012 |
| Summary | PURPOSE:We examined the efficacy of retinol palmitate (VApal) for dry eyes using dry eye model rabbits whose lacrimal glands were resected.MATERIALS AND METHODS:After alkaline injury on keratoconjunctival epithelium, VApal eye drops were administered 6 times a day for 7 days. The efficacy of VApal was also compared with that of 0.1% hyaluronic acid eye drops.RESULTS:The fluorescein staining and rose bengal scores showed a significant decrease compared with the score in the vehicle group at 7 days (P < 0.05) in the 1000 IU/mL VApal group and at both 3 days (P < 0.05) and 7 days (P < 0.01) in the 1500 IU/mL VApal group. Histological examination revealed recovery of the corneal epithelium, and PAS staining disclosed the recovery of mucin-producing lower palpebral conjunctival goblet cells after 7 days in the 1500 IU/mL VApal group compared with the vehicle group. Results from impression cytology showed a significant increase in density of conjunctival goblet cells compared with that in the vehicle group after 7 days in the 1000 IU/mL VApal group and after 3 and 7 days in the 1500 IU/mL VApal group. There were no significant changes in tear flow in either group. Topical application of VApal at 1500 IU/mL showed greater improvement than 0.1% hyaluronic acid in both fluorescein and rose bengal score and in the density of conjunctival goblet cells.CONCLUSION:It is suggested that VApal is effective for the improvement of keratoconjunctival epithelial damage associated with tear abnormalities, such as dry eyes. |
| DOI | 10.2147/OPTH.S35584 |
| PMID | 23055683 |