ストウ　チカコ   SUTO Chikako   須藤　史子    所属   医学部 医学科（附属足立医療センター）    職種   教授
論文種別	原著
言語種別	英語
査読の有無	査読なし
表題	Efficacy of retinol palmitate eye drops for dry eye in rabbits with lacrimal gland resection.
掲載誌名	正式名：Clinical ophthalmology (Auckland, N.Z.) 略　 称：Clin Ophthalmol ISSNコード：11775483/11775467
巻・号・頁	6,pp.1585-1593
著者・共著者	Odaka Akito†, Toshida Hiroshi, Ohta Toshihiko, Tabuchi Nobuhito, Koike Daisuke, Suto Chikako, Murakami Akira
発行年月	2012
概要	PURPOSE:We examined the efficacy of retinol palmitate (VApal) for dry eyes using dry eye model rabbits whose lacrimal glands were resected.MATERIALS AND METHODS:After alkaline injury on keratoconjunctival epithelium, VApal eye drops were administered 6 times a day for 7 days. The efficacy of VApal was also compared with that of 0.1% hyaluronic acid eye drops.RESULTS:The fluorescein staining and rose bengal scores showed a significant decrease compared with the score in the vehicle group at 7 days (P < 0.05) in the 1000 IU/mL VApal group and at both 3 days (P < 0.05) and 7 days (P < 0.01) in the 1500 IU/mL VApal group. Histological examination revealed recovery of the corneal epithelium, and PAS staining disclosed the recovery of mucin-producing lower palpebral conjunctival goblet cells after 7 days in the 1500 IU/mL VApal group compared with the vehicle group. Results from impression cytology showed a significant increase in density of conjunctival goblet cells compared with that in the vehicle group after 7 days in the 1000 IU/mL VApal group and after 3 and 7 days in the 1500 IU/mL VApal group. There were no significant changes in tear flow in either group. Topical application of VApal at 1500 IU/mL showed greater improvement than 0.1% hyaluronic acid in both fluorescein and rose bengal score and in the density of conjunctival goblet cells.CONCLUSION:It is suggested that VApal is effective for the improvement of keratoconjunctival epithelial damage associated with tear abnormalities, such as dry eyes.
DOI	10.2147/OPTH.S35584
PMID	23055683