SUTO Chikako    Department   School of Medicine(Tokyo Women's Medical University Adachi Medical Center), School of Medicine    Position   Professor
Article types	Original article
Language	English
Peer review	Non peer reviewed
Title	Efficacy and safety of prophylactic intracameral moxifloxacin injection in Japan.
Journal	Formal name：Journal of cataract and refractive surgery Abbreviation：J Cataract Refract Surg ISSN code：18734502/08863350
Volume, Issue, Page	39(11),pp.1702-1706
Author and coauthor	Matsuura Kazuki,† Miyoshi Teruyuki, Suto Chikako, Akura Junsuke, Inoue Yoshitsugu
Publication date	2013/11
Summary	PURPOSE:To report endophthalmitis rates after cataract surgery and the incidence of complications after intracameral moxifloxacin injection.SETTING:Nineteen clinics in Japanese institutions.DESIGN:Retrospective survey cohort study.METHODS:The number of surgeries and endophthalmitis cases in the past 4 years before and after the introduction of intracameral moxifloxacin was evaluated. The survey was performed by mail or interview in February 2013.RESULTS:All institutions used total-replacement administration rather than small-volume injection. At 3 institutions, 50 to 100 μg/mL moxifloxacin; at 9 institutions, 100 to 300 μg/mL moxifloxacin; and at 7 institutions, 500 μg/mL moxifloxacin was administered. The highest concentration (500 μg/mL) was administered in 14,124 cases. Endophthalmitis cases occurred 1 month or sooner postoperatively in 8 of 15,958 cases (ie, 1 in 1955) without intracameral moxifloxacin administration and in 3 of 18,794 cases (ie, 1 in 6265) with intracameral moxifloxacin administration.CONCLUSIONS:Intracameral moxifloxacin (50 to 500 μg/mL) administration decreased the risk for endophthalmitis by 3-fold. In more than 18,000 cases, moxifloxacin administration of 500 μg/mL or less did not result in severe complications, such as toxic anterior segment syndrome or corneal endothelial cell loss.
DOI	10.1016/j.jcrs.2013.05.036
PMID	24054967