|
TANIAI Makiko
Department School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine Position Associate Professor |
|
| Article types | Original article |
| Language | English |
| Peer review | Non peer reviewed |
| Title | Outcomes of fatty liver disease with and without metabolic comorbidities and risk factors for mortality |
| Journal | Formal name：JGH open Abbreviation：JGH Open ISSN code：23979070/23979070 |
| Domestic / Foregin | Foregin |
| Volume, Issue, Page | 7(6),pp.410-418 |
| Author and coauthor | OGASAWARA Yuri, KOGISO Tomomi*, HORIUCHI Kentaro, TANIAI Makiko, TOKUSHIGE Katsutoshi |
| Publication date | 2023/05 |
| Summary | BACKGROUND AND AIM:As the clinical course of metabolic-associated fatty liver disease (MAFLD) is unclear, we compared the clinical courses of MAFLD and non-alcoholic FLD (NAFLD).METHODS:Asian FLD patients (n = 987) from 1991 to 2021 (biopsy-proven in 939) were enrolled. The patients were divided into NAFLD (N-alone, n = 92), both MAFLD and N (M&N, n = 785), and M-alone (n = 90) groups. Clinical features, complications, and survival rates were compared among the three groups. Risk factors of mortality were subjected to Cox regression analysis.RESULTS:The N-alone group patients were significantly younger (N alone, M&N, and M alone: 50, 53, and 57 years, respectively), more frequently male (54.3%, 52.6%, and 37.8%), and had a low body mass index (BMI, 23.1, 27.1, and 26.7 kg/m2) and FIB-4 index (1.20, 1.46, and 2.10). Hypopituitarism (5.4%) and hypothyroidism (7.6%) were significantly observed in the N-alone group. Hepatocellular carcinoma (HCC) developed in 0.0%, 4.2%, and 3.5% of the cases, and extrahepatic malignancies in 6.8%, 8.4%, and 4.7% of the cases, respectively, with no significant differences. The cardiovascular event rate was significantly higher in the M-alone group (1, 37, and 11 cases, P < 0.01). Survival rates were similar among the three groups. Risk factors for mortality were age and BMI in the N-alone group; age, HCC, alanine transaminase, and FIB-4 in the M&N group; and FIB-4 in the M-alone group.CONCLUSION:Different risk factors for mortality may exist among the FLD groups. |
| DOI | 10.1002/jgh3.12898 |
| PMID | 37359113 |