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TANIAI Makiko
Department School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine Position Associate Professor |
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| Article types | Original article |
| Language | English |
| Peer review | Non peer reviewed |
| Title | Prevalence of fatty liver disease after liver transplantation and risk factors for recipients and donors. |
| Journal | Formal name：Annals of hepatology Abbreviation：Ann Hepatol ISSN code：16652681/16652681 |
| Domestic / Foregin | Foregin |
| Volume, Issue, Page | 27(2),pp.100670 |
| Author and coauthor | HORIUCHI Kentaro, KOGISO Tomomi*, SAGAWA Takaomi, TANIAI Makiko, KOTERA Yoshihito, EGAWA Hiroto, TOKUSHIGE Katsutoshi |
| Publication date | 2022 |
| Summary | INTRODUCTION AND OBJECTIVES:Fatty liver disease (FLD) may develop in liver transplant recipients. We investigated the recipient and donor risk factors for FLD development after liver transplantation (LT).METHODS:A total of 108 liver transplant recipients (54 men [50.0%]; median age, 52 [20-68] years) treated from 2011-2020 was enrolled. Three recipients died at < 3 months as a result of infection or blood flow impairment, and were excluded from the long-term FLD study. On evaluation of 88 prospective living donors, fatty liver was observed in 21. The prevalence and risk factors for FLD and survival were evaluated.RESULTS:After LT, 28 of 105 recipients (26.7%) developed FLD. FLD was more common in patients with a high body mass index (BMI) and dyslipidemia (both p < 0.01), primary nonalcoholic steatohepatitis (p = 0.02), after living-donor LT (p = 0.03) and everolimus (EVL) use (p = 0.08). Factors predictive of FLD included EVL use and a high BMI (hazard ratios = 3.00 and 1.34; p = 0.05 and p < 0.01, respectively). Sixteen donors lost 6.5 kg (range: 2.0-16.0 kg) of body weight prior to LT. However, there were no cases of primary non-function, which did not affect the FLD prevalence. Development of FLD did not have a negative impact on LT outcome; the 5-year survival rate was 92.6%.CONCLUSIONS:Recipient factors were more important than donor factors for FLD onset after LT. |
| DOI | 10.1016/j.aohep.2022.100670 |
| PMID | 35051631 |