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タニアイ マキコ
TANIAI Makiko
谷合 麻紀子 所属 医学部 医学科（東京女子医科大学病院） 職種 准教授 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読なし |
| 表題 | The transition in the etiologies of hepatocellular carcinoma-complicated liver cirrhosis in a nationwide survey of Japan. |
| 掲載誌名 | 正式名：Journal of gastroenterology 略 称：J Gastroenterol ISSNコード：14355922/09441174 |
| 掲載区分 | 国外 |
| 巻・号・頁 | 56(2),pp.158-167 |
| 著者・共著者 | Enomoto Hirayuki, Ueno Yoshiyuki, Hiasa Yoichi, Nishikawa Hiroki, Hige Shuhei, Takikawa Yasuhiro, Taniai Makiko, Ishikawa Toru, Yasui Kohichiroh, Takaki Akinobu, Takaguchi Koichi, Ido Akio, Kurosaki Masayuki, Kanto Tatsuya, Nishiguchi Shuhei, |
| 発行年月 | 2021/02 |
| 概要 | BACKGROUND:We recently reported the real-world changes in the etiologies of liver cirrhosis (LC) based on nationwide survey data and assessed the etiologies of LC with hepatocellular carcinoma (HCC).METHODS:Fifty-five participants from 68 institutions provided data on 23,637 patients with HCC-complicated LC. The changing trends in etiologies were assessed. We further analyzed the data from 29 hospitals that provided the annual number of newly identified HCC-complicated LC patients from 2008 to 2016 (N = 9362) without any missing years and assessed the transition in the real number of newly identified HCC-complicated LC cases.RESULTS:In the overall cohort, hepatitis C virus (HCV) infection (60.3%) and hepatitis B virus (HBV) infection (12.9%) were the leading and third-most common causes of HCC-complicated LC in Japan, respectively. HCV infection was found to be the leading cause throughout Japan. The rate of viral hepatitis-related HCC decreased from 85.3 to 64.4%. Among non-viral etiologies, notable increases were observed in nonalcoholic steatohepatitis (NASH)-related HCC (from 1.5 to 7.2%) and alcoholic liver disease (ALD)-related HCC (from 8.5 to 18.6%). Regarding the real number of newly diagnosed patients, the number of patients with viral hepatitis-related HCC decreased, while the number of patients with non-viral HCC, particularly NASH-related HCC, increased.CONCLUSIONS:Viral hepatitis has remained the main cause of HCC in Japan. However, the decrease in viral hepatitis-related HCC, particularly HCV-related HCC highly contributed to the etiological changes. In addition, the increased incidence of non-viral HCC, particularly NASH-related HCC, was involved in the changing etiologies of HCC-complicated LC in Japan. |
| DOI | 10.1007/s00535-020-01748-x |
| PMID | 33219410 |