Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine
   Position   Associate Professor
Article types Original article
Language English
Peer review Non peer reviewed
Title Evidence-based clinical practice guidelines for liver cirrhosis 2020.
Journal Formal name:Hepatology research
Abbreviation:Hepatol Res
ISSN code:13866346/13866346
Domestic / ForeginForegin
Volume, Issue, Page 51(7),pp.725-749
Author and coauthor Yoshiji Hitoshi, Nagoshi Sumiko, Akahane Takemi, Asaoka Yoshinari, Ueno Yoshiyuki, Ogawa Koji, Kawaguchi Takumi, Kurosaki Masayuki, Sakaida Isao, Shimizu Masahito, Taniai Makiko, Terai Shuji, Nishikawa Hiroki, Hiasa Yoichi, Hidaka Hisashi, Miwa Hiroto, Chayama Kazuaki, Enomoto Nobuyuki, Shimosegawa Tooru, Takehara Tetsuo, Koike Kazuhiko
Publication date 2021/07
Summary The first edition of the clinical practice guidelines for liver cirrhosis was published in 2010, and the second edition was published in 2015 by the Japanese Society of Gastroenterology (JSGE). The revised third edition was recently published in 2020. This version has become a joint guideline by the JSGE and the Japanese Society of Hepatology (JSH). In addition to the clinical questions (CQs), background questions (BQs) are new items for basic clinical knowledge, and future research questions (FRQs) are newly added clinically important items. Concerning the clinical treatment of liver cirrhosis, new findings have been reported over the past 5 years since the second edition. In this revision, we decided to match the international standards as much as possible by referring to the latest international guidelines. Newly developed agents for various complications have also made great progress. In comparison with the latest global guidelines, such as the European Association for the Study of the Liver (EASL) and American Association for the Study of Liver Diseases (AASLD), we are introducing data based on the evidence for clinical practice in Japan. The flowchart for nutrition therapy was reviewed to be useful for daily medical care by referring to overseas guidelines. We also explain several clinically important items that have recently received focus and were not mentioned in the last editions. This digest version describes the issues related to the management of liver cirrhosis and several complications in clinical practice. The content begins with a diagnostic algorithm, the revised flowchart for nutritional therapy, and refracted ascites, which are of great importance to patients with cirrhosis. In addition to the updated antiviral therapy for hepatitis B and C liver cirrhosis, the latest treatments for non-viral cirrhosis, such as alcoholic steatohepatitis/non-alcoholic steatohepatitis (ASH/NASH) and autoimmune-related cirrhosis, are also described. It also covers t
DOI 10.1111/hepr.13678
PMID 34228859