Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine
   Position   Associate Professor
Article types Review article
Language English
Peer review Peer reviewed
Title Alcohol and hepatocarcinogenesis.
Journal Formal name:Clinical and molecular hepatology
Abbreviation:Clin Mol Hepatol
ISSN code:2287285X/22872728
Domestic / ForeginForegin
Volume, Issue, Page 26(4),pp.736-741
Author and coauthor TANIAI Makiko†
Authorship Lead author
Publication date 2020/10
Summary An excessive alcohol intake may result in fatty liver, acute/chronic hepatitis, cirrhosis, and lead to hepatocellular carcinoma (HCC). The aim of this review is to clarify the present condition and the mechanisms of alcohol-related hepatocarcinogenesis and clinical risk factors for alcohol-related HCC. There are several possible mechanisms through which alcohol may induce hepatocarcinogenesis, including the mutagenic effects of acetaldehyde toxicity through the formation of protein and DNA adducts and the production of reactive oxygen species due to the excessive hepatic deposition of iron, changes to lipid peroxidation and metabolism, inflammation and an impaired immune response and modifications to DNA methylation. Furthermore, it has been reported that alcohol accelerates liver carcinogenesis through several signaling pathways including gut-liver axis. From a clinical perspective, it is well known that alcohol interacts with other factors, such as age, gender, viral hepatitis, obesity, and diabetes leading to an increased risk of HCC.
DOI 10.3350/cmh.2020.0203
PMID 33053943