Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine
   Position   Associate Professor
Article types Original article
Language English
Peer review Peer reviewed
Title Transition in the etiology of liver cirrhosis in Japan: a nationwide survey.
Journal Formal name:Journal of gastroenterology
Abbreviation:J Gastroenterol
ISSN code:14355922/09441174
Volume, Issue, Page 55(3),pp.353-362
Author and coauthor Enomoto Hirayuki, Ueno Yoshiyuki, Hiasa Yoichi, Nishikawa Hiroki, Hige Shuhei, Takikawa Yasuhiro, Taniai Makiko, Ishikawa Toru, Yasui Kohichiroh, Takaki Akinobu, Takaguchi Koichi, Ido Akio, Kurosaki Masayuki, Kanto Tatsuya, Nishiguchi Shuhei,
Publication date 2020/03
Summary BACKGROUND:To assess the recent real-world changes in the etiologies of liver cirrhosis (LC) in Japan, we conducted a nationwide survey in the annual meeting of the Japan Society of Hepatology (JSH).METHODS:We investigated the etiologies of LC patients accumulated from 68 participants in 79 institutions (N = 48,621). We next assessed changing trends in the etiologies of LC by analyzing cases in which the year of diagnosis was available (N = 45,834). We further evaluated the transition in the real number of newly identified LC patients by assessing data from 36 hospitals with complete datasets for 2008-2016 (N = 18,358).RESULTS:In the overall data, HCV infection (48.2%) was the leading cause of LC in Japan, and HBV infection (11.5%) was the third-most common cause. Regarding the transition in the etiologies of LC, the contribution of viral hepatitis-related LC dropped from 73.4 to 49.7%. Among the non-viral etiologies, alcoholic-related disease (ALD) and nonalcoholic steatohepatitis (NASH)-related LC showed a notable increase (from 13.7 to 24.9% and from 2.0 to 9.1%, respectively). Regarding the real numbers of newly diagnosed patients from 2008 to 2016, the numbers of patients with viral hepatitis-related LC decreased, while the numbers of patients with non-viral LC increased.CONCLUSIONS:HCV has remained the main cause of LC in Japan; however, the contribution of viral hepatitis as an etiology of LC is suggested to have been decreasing. In addition, non-viral LC, such as ALD-related LC and NASH-related LC, is suggested to have increased as etiologies of LC in Japan.
DOI 10.1007/s00535-019-01645-y
PMID 31768801