Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine
   Position   Associate Professor
Article types Case report
Language English
Peer review Peer reviewed
Title An intensive medical care network led to successful living-donor liver transplantation in late-onset hepatic failure with disseminated Staphylococcus aureus infection
Journal Formal name:Clinical journal of gastroenterology
Abbreviation:Clin J Gastroenterol
ISSN code:(1865-7265)1865-7265(Linking)
Domestic / ForeginForegin
Volume, Issue, Page 12(2),pp.112-119
Author and coauthor KURE Rie†, UEHARA Natsumi, INOUE Kazuyuki, KOGISO Tomomi, KODAMA Kazuhisa, TANIAI Makiko, TOKUSHIGE Katsutoshi, NAKAO Masayuki, EGAWA Hiroto, YAMAMOTO Masakazu
Publication date 2019/04
Summary Here, we describe a 42-year-old male patient with late-onset hepatic failure (LOHF) due to acute-onset autoimmune hepatitis. At first, his response to steroid therapy was good, but hepatitis relapsed during steroid pulse therapy. Deterioration of liver function caused LOHF, and LOHF has a poor prognosis, particularly when it is complicated by infection. Systemic infection by Staphylococcus aureus resulted in a skin rash and septic pulmonary embolism, and is an absolute contraindication for liver transplantation (LT). In this treatment network, hepatologists and a transplant surgeon cooperated to overcome severe infection and their efforts led to successful transplantation. On-line hemodiafiltration is an indispensable treatment option for acute liver failure. Infection control is crucial for LT and an intensive medical care network led to successful living-donor LT.
DOI 10.1007/s12328-018-0904-y
PMID 30218430