YAMATO Masayuki
   Department   Research Institutes and Facilities, Research Institutes and Facilities
   Position   Professor
Article types Original article
Language English
Peer review Peer reviewed
Title Cell sheet transplantation prevents inflammatory adhesions: A new treatment for adhesive otitis media.
Journal Formal name：Regenerative Therapy
ISSN code：2352-3204
Domestic / ForeginForegin
Volume, Issue, Page 18,pp.457-463
Author and coauthor YAMAMOTO Kazuhisa†*, MORINO Tsunetaro, KASAI Yoshiyuki, KIKUCHI Shun, KOMORI Manabu, YAMATO Masayuki, KOJIMA Hiromi
Publication date 2021/12
Summary Introduction:We developed a new treatment method that combines tympanoplasty with transplantation of autologous cultured nasal mucosal epithelial cell sheets to regenerate the mucosa of patients with adhesive otitis media, which has been difficult to treat effectively. We verified whether this procedure could be performed safely and measured its therapeutic efficacy.Methods:Autologous nasal mucosal epithelial cell sheets were manufactured at a good manufacturing practice-compliant cell processing facility using autologous nasal mucosal tissue. We performed tympanoplasty and transplanted the cell sheets into the middle ear cavity in six patients with adhesive otitis media.Results:The manufactured autologous cultured epithelial cell sheets met the predetermined quality standards and were successfully transplanted safely in all cases. Computed tomography findings after cell sheet transplantation showed that aeration in the tympanic cavity was maintained or restored in five of the six patients (83.3%). Four of the six (66.7%) patients had postoperative air-bone gap within 20 dB, which is considered a postoperative success in tympanoplasty for chronic middle ear disease.Conclusions:The results of this clinical study suggest that tympanoplasty with cell sheet transplantation can be used to treat adhesive otitis media by reliably preventing re-adhesion of the tympanic membrane.
DOI 10.1016/j.reth.2021.10.001
PMID 34805451