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YAMATO Masayuki
Department Research Institutes and Facilities, Research Institutes and Facilities Position Professor |
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| Article types | Original article |
| Language | English |
| Peer review | Peer reviewed |
| Title | Corneal epithelial stem cell delivery using cell sheet engineering: not lost in transplantation. |
| Journal | Formal name：Journal of drug targeting Abbreviation：J Drug Target ISSN code：(1061-186X)1026-7158(Linking) |
| Domestic / Foregin | Foregin |
| Volume, Issue, Page | 14(7),pp.471-82 |
| Author and coauthor | YANG Joseph†, YAMATO Masayuki, NISHIDA Kohji, HAYASHIDA Yasutaka, SHIMIZU Tatsuya, KIKUCHI Akihiko, TANO Yasuo, OKANO Teruo* |
| Authorship | 2nd author |
| Publication date | 2006/11 |
| Summary | Cell-based therapies have now generated significant interest as novel drug delivery systems, with various adult cell types used in treating a wide range of diseases. To overcome the limits that restrict treatments for corneal surface dysfunction, corneal epithelial stem cells expanded ex vivo have been applied as an alternative approach. While previous studies used various carrier substrates, we present a novel method using cell sheet engineering with temperature-responsive culture dishes to create carrier-free corneal epithelial stem cell sheets that can be transplanted without sutures. Results from clinical trials reveal successful transplantation with the recovery of lost visual acuity in all cases. Cell sheet engineering, therefore, presents a novel method for the delivery of corneal epithelial stem cells, and can also be applied for other approaches of cellular therapeutics. |
| DOI | 10.1080/10611860600847997 |
| PMID | 17062394 |