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YAMATO Masayuki
Department Research Institutes and Facilities, Research Institutes and Facilities Position Professor |
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| Article types | Original article |
| Language | English |
| Peer review | Peer reviewed |
| Title | Nectin-3 expression is elevated in limbal epithelial side population cells with strongly expressed stem cell markers. |
| Journal | Formal name：Biochemical and biophysical research communications Abbreviation：Biochem Biophys Res Commun ISSN code：(1090-2104)0006-291X(Linking) |
| Domestic / Foregin | Foregin |
| Volume, Issue, Page | 389(2),pp.274-8 |
| Author and coauthor | KUSANAGI Risa†, UMEMOTO Terumasa, YAMATO Masayuki, MATSUZAKI Yu, NISHIDA Kohji, KOBAYASHI Yoshiro, FUKAI Fumio, OKANO Teruo* |
| Publication date | 2009/11 |
| Summary | Corneal epithelial stem cells (CESCs) are essential for maintaining the ocular surface. However, the lack of surface markers for CESCs remains a serious obstacle in the identification of CESCs. Previously, we showed that rabbit limbal epithelial side population (rLE-SP) cells exhibited stem cell phenotypes including increased expression of CD61, a marker for mouse hematopoietic stem cells. Here, we demonstrate that nectin-3, an immunoglobulin-like cell-cell adhesion molecule, is highly expressed in rLE-SP cells. Additionally, nectin-3(+) cells were significantly enriched among CD61(+)rLE-SP cells as compared to CD61(-)rLE-SP cells. In mouse bone marrow side population cells, a correlation between expression of nectin-3 and CD61 was also observed. These data strongly suggest that nectin-3 may contribute to the identification of CESCs. |
| DOI | 10.1016/j.bbrc.2009.08.130 |
| PMID | 19716807 |