ヤマト マサユキ   YAMATO Masayuki
  大和 雅之
   所属   研究施設 研究施設
   職種   教授
論文種別 原著
言語種別 英語
査読の有無 査読あり
表題 Nectin-3 expression is elevated in limbal epithelial side population cells with strongly expressed stem cell markers.
掲載誌名 正式名:Biochemical and biophysical research communications
略  称:Biochem Biophys Res Commun
ISSNコード:(1090-2104)0006-291X(Linking)
掲載区分国外
巻・号・頁 389(2),274-8頁
著者・共著者 KUSANAGI Risa†, UMEMOTO Terumasa, YAMATO Masayuki, MATSUZAKI Yu, NISHIDA Kohji, KOBAYASHI Yoshiro, FUKAI Fumio, OKANO Teruo*
発行年月 2009/11
概要 Corneal epithelial stem cells (CESCs) are essential for maintaining the ocular surface. However, the lack of surface markers for CESCs remains a serious obstacle in the identification of CESCs. Previously, we showed that rabbit limbal epithelial side population (rLE-SP) cells exhibited stem cell phenotypes including increased expression of CD61, a marker for mouse hematopoietic stem cells. Here, we demonstrate that nectin-3, an immunoglobulin-like cell-cell adhesion molecule, is highly expressed in rLE-SP cells. Additionally, nectin-3(+) cells were significantly enriched among CD61(+)rLE-SP cells as compared to CD61(-)rLE-SP cells. In mouse bone marrow side population cells, a correlation between expression of nectin-3 and CD61 was also observed. These data strongly suggest that nectin-3 may contribute to the identification of CESCs.
DOI 10.1016/j.bbrc.2009.08.130
PMID 19716807