ヤマト マサユキ   YAMATO Masayuki
  大和 雅之
   所属   研究施設 研究施設
   職種   教授
論文種別 原著
言語種別 英語
査読の有無 査読あり
表題 Thoracoscopic cell sheet transplantation with a novel device
掲載誌名 正式名:Journal of Tissue Engineering and Regenerative Medicine
略  称:J Tissue Eng Regen Med
ISSNコード:19327005
掲載区分国外
巻・号・頁 3(4),255-259頁
著者・共著者 MAEDA Masanori†,YAMATO Masayuki, KANZAKI Masato, ISEKI Hiroshi, OKANO Teruo
発行年月 2009/06
概要 Regenerative medicine with transplantable cell sheets fabricated on temperature-responsive culture surfaces has been successfully achieved in clinical applications, including skin and cornea treatment. Previously, we reported that transplantation of fibroblast cell sheets to wounded lung had big advantages for sealing intraoperative air leaks compared with conventional materials. Here, we report a novel device for minimally invasive transplantation of cell sheets in endoscopic surgery, such as video-assisted thoracoscopic surgery (VATS). The novel device was designed with a computer-aided design (CAD) system, and the three-dimensional (3D) data were transferred to a 3D printer. With this rapid prototyping system, the cell sheet transplantation device was fabricated using a commercially available photopolymer approved for clinical use. Square cell sheets (24 x 24 mm) were successfully transplanted onto wound sites of porcine lung placed in a human body model, with the device inserted through a 12 mm port. Such a device would enable less invasive transplantation of cell sheets onto a wide variety of internal organs.
DOI 10.1002/term.161.
PMID 19382117