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長尾 充展
Department School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine Position Associate Professor |
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| Article types | Original article |
| Language | English |
| Peer review | Peer reviewed |
| Title | Heterogeneity of cerebral blood flow in frontotemporal lobar degeneration and Alzheimer's disease. |
| Journal | Formal name：European journal of nuclear medicine and molecular imaging Abbreviation：Eur J Nucl Med Mol Imaging ISSN code：(1619-7070)1619-7070(Linking) |
| Domestic / Foregin | Foregin |
| Volume, Issue, Page | 31(2),pp.162-168 |
| Author and coauthor | Nagao Michinobu, Sugawara Yoshifumi, Ikeda Manabu, Fukuhara Ryuji, Hokoishi Kazuhiko, Murase Kenya, Mochizuki Teruhito, Miki Hitoshi, Kikuchi Takanori |
| Authorship | Lead author,Corresponding author |
| Publication date | 2004/02 |
| Summary | This study was designed to quantify the heterogeneity on cerebral blood flow single-photon emission tomography (SPET) images in frontotemporal lobar degeneration (FTLD) and Alzheimer's disease (AD) using a three-dimensional fractal analysis. Twenty-one FTLD patients, 21 AD patients and 11 healthy controls underwent technetium-99m hexamethylpropylene amine oxime SPET scanning. Patients with FTLD and AD matched for sex, age and the severity of dementia as estimated with the Clinical Dementia Rating and were determined to be in the early stage of illness. We delineated the SPET images using a 35% cut-off and a 50% cut-off of the maximal voxel radioactivity and measured the number of voxels included in the contours of two different cut-offs. The fractal dimension (FD) was calculated by relating the logarithms of the cut-offs and the numbers of voxels, and it was defined as the heterogeneity of the cerebral perfusion. We divided the SPET images into two sets, anterior and posterior, with equal numbers of coronal SPET slices. We calculated total FD, anterior FD and posterior FD for total, anterior and posterior SPET images. Anterior FDs for FTLD and AD were 1.55 +/- 0.34 and 1.24 +/- 0.19 (P = 0.0002). The ratios of anterior to posterior FD for FTLD and AD were 1.81 +/- 0.41 and 1.32 +/- 0.14 (P < 0.0001). Use of the anterior FD and the ratio of anterior to posterior FD separated FTLD patients from AD patients and controls with a sensitivity of 85.7% and a specificity of 93.8%. Anterior FD and the ratio of anterior to posterior FD may be useful in distinguishing FTLD from AD. |
| DOI | 10.1007/s00259-003-1343-6 |
| PMID | 15129697 |