|
ハギワラ シヨウタロウ
萩原 將太郎 所属 医学部 医学科（東京女子医科大学病院） 職種 非常勤講師 |
|
| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Occupational exposure of platinum-based anti-cancer drugs: five-year monitoring of hair and environmental samples in a single hospital. |
| 掲載誌名 | 正式名：Journal of occupational medicine and toxicology (London, England) 略 称：J Occup Med Toxicol ISSNコード：17456673/17456673 |
| 掲載区分 | 国外 |
| 巻・号・頁 | 15,pp.29 |
| 著者・共著者 | Hori Ai†, Shimura Mari, Iida Yutaka, Yamada Kazuhiko, Nohara Kyoko, Ichinose Takayuki, Yamashita Ai, Shirataki Junko, Hagiwara Shotaro |
| 担当区分 | 最終著者 |
| 発行年月 | 2020 |
| 概要 | Background:Occupational exposure to chemotherapeutic agents in hospitals is a critical issue. Here, we focused on occupational exposure to platinum-based anti-cancer drugs (PDs) by evaluating platinum concentrations in hair and environmental workplace samples to monitor the risk among workers.Methods:Hospital workers who dealt with or without PDs, patients treated with PDs, and non-medical office workers outside the hospital donated hair samples and completed a questionnaire regarding their history of handling PDs, including any incidents. Hair samples were collected and surface wipe sampling was performed in July 2010 and April 2015, before and after moving to a new building and introducing a revised safety program in August 2010. Samples were analyzed by inductively coupled plasma-mass spectrometry.Results:Platinum concentrations in hair from PDs-handling workers was significantly higher than in non-PDs-handling workers (P = 0.045), although 50 times lower than that from PDs-treated patients. Platinum concentrations in the hospital environment had decreased at the second survey 5 years later but had not changed significantly in the hair samples from hospital workers.Conclusion:Platinum concentrations in hair are likely dependent on the frequency of handling PDs. Reduced environmental contamination from PDs did not influence platinum levels in hospital workers' hair. Continuous monitoring by measuring platinum concentrations in the environment and in hair would provide information regarding these issues. |
| DOI | 10.1186/s12995-020-00280-1 |
| PMID | 33005211 |