KISHINO Maiko
Department School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine Position Assistant Professor |
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Article types | Original article |
Language | English |
Peer review | Non peer reviewed |
Title | Clinical presentation and therapeutic outcome of patients with jackhammer esophagus-a multicenter cohort study in Japan. |
Journal | Formal name:Esophagus : official journal of the Japan Esophageal Society Abbreviation:Esophagus ISSN code:16129067/16129059 |
Domestic / Foregin | Foregin |
Volume, Issue, Page | 19(3),pp.393-400 |
Author and coauthor | HOSAKA Hiroko, KAWAMI Noriyuki, MANABE Noriaki, KURIBAYASHI Shiko, SATO Hiroki, FUNAKI Yasushi, AYAKI Maki, HARA Ken, UEDA Chise, MATSUMURA Tomoaki, FUJIWARA Yasuhiro, WADA Masafumi, KISHINO Maiko, YANO Fumiaki, MASAOKA Tatsuhiro, ISHIMURA Norihisa, AKIYAMA Junichi, OCHIAI Yorinari, URAOKA Toshio, IWAKIRI Katsuhiko |
Publication date | 2022/07 |
Summary | BACKGROUND:Jackhammer esophagus (JE) is a hypercontractile esophageal motility disorder diagnosed using high-resolution manometry (HRM). We sought to determine the clinical presentation and therapeutic data of patients with JE in Japan.METHODS:The study included patients with JE, diagnosed through HRM performed for suspicious esophageal motility disorders. Demographics, esophagogastroduodenoscopy, radiology, and therapy data were collected from patient charts.RESULTS:Among the 4,412 HRM tests performed, 89 patients (61.6 ± 13.4 years; 64 males, 25 females) were diagnosed with JE (2.0%). Dysphagia was the most frequent symptom (80%), followed by chest pain (40%) and heartburn (25%). Esophagogastroduodenoscopy showed abnormal findings in 32% of patients: corkscrew/rosary beads appearance in 26%, narrowing in 11%. Eosinophilic infiltration (> 15 eosinophils/high power field) was diagnosed in 21%. Esophagography showed abnormal findings in 9% of the patients. For the initial therapy, 47 patients received medical treatment followed by peroral endoscopic myotomy (21 patients) and laparoscopic myotomy (two patients). Thirteen patients did not receive any treatment and 10 of those (77%) reported spontaneous resolution of symptoms. Patients who required invasive treatment experienced severe disability in their quality of life and greater maximal distal contractile integral than those who did not.CONCLUSIONS:HRM showed that the prevalence of JE was very low (2%). Esophagogastroduodenoscopy revealed some characteristic features of JE in patients. Some patients showed improvement of symptoms without invasive treatments. Follow-up with/without medical treatment should be considered before performing invasive treatment in patients whose distal contractile integral is relatively low and the quality of life is not impaired. |
DOI | 10.1007/s10388-022-00916-7 |
PMID | 35249162 |