Michio Otsuki
   Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine
   Position   Professor and Division head
Article types Original article
Language English
Peer review Peer reviewed
Title Plasma NfL is associated with mild cognitive decline in patients with diabetes.
Journal Formal name：Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society
Abbreviation：Psychogeriatrics
ISSN code：14798301/13463500
Domestic / ForeginForegin
Volume, Issue, Page 22(3),pp.353-359
Author and coauthor Marutani Noriko, Akamine Shoshin, Kanayama Daisuke, Gotoh Shiho, Yanagida Kanta, Maruyama Riki, Mori Kohji, Miyamoto Tesshin, Adachi Hiroyoshi, Sakagami Yukako, Yoshiyama Kenji, Hotta Maki, Nagase Aki, Kozawa Junji, Maeda Norikazu, Otsuki Michio, Matsuoka Takaaki, Iwahashi Hiromi, Shimomura Iichiro, Murayama Norihito, Watanabe Hiroshi, Ikeda Manabu, Mizuta Ichiro, Kudo Takashi
Publication date 2022/05
Summary BACKGROUND:Patients with diabetes are at a higher risk for cognitive decline. Thus, biomarkers that can provide early and simple detection of cognitive decline are required. Neurofilament light chain (NfL) is a cytoskeletal protein that constitutes neural axons. Plasma NfL levels are elevated when neurodegeneration occurs. Here, we investigated whether plasma NfL levels were associated with cognitive decline in patients with type 2 diabetes.METHOD:This study included 183 patients with type 2 diabetes who visited Osaka University Hospital. All participants were tested for cognitive function using the Mini-Mental State Examination (MMSE) and the Rivermead Behavioural Memory Test (RBMT). NfL levels were analysed in the plasma and the relationship between NfL and cognitive function was examined.RESULTS:Lower RBMT-standardized profile scores (SPS) or MMSE scores correlated with higher plasma NfL levels (one-way analysis of variance: MMSE, P = 0.0237; RBMT-SPS, P = 0.0001). Furthermore, plasma NfL levels (β = -0.34, P = 0.0005) and age (β = -0.19, P = 0.016) were significantly associated with the RBMT score after multivariable regression adjustment.CONCLUSIONS:Plasma NfL levels were correlated with mild cognitive decline which is detected by the RBMT but not the MMSE in patients with type 2 diabetes. This suggests that plasma NfL levels may provide a valuable clinical tool for identifying mild cognitive decline in patients with diabetes.
DOI 10.1111/psyg.12819
PMID 35279914