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オオツキ ミチオ
Michio Otsuki
大月 道夫 所属 医学部 医学科（東京女子医科大学病院） 職種 教授・基幹分野長 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Plasma NfL is associated with mild cognitive decline in patients with diabetes. |
| 掲載誌名 | 正式名：Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society 略 称：Psychogeriatrics ISSNコード：14798301/13463500 |
| 掲載区分 | 国外 |
| 巻・号・頁 | 22(3),pp.353-359 |
| 著者・共著者 | Marutani Noriko, Akamine Shoshin, Kanayama Daisuke, Gotoh Shiho, Yanagida Kanta, Maruyama Riki, Mori Kohji, Miyamoto Tesshin, Adachi Hiroyoshi, Sakagami Yukako, Yoshiyama Kenji, Hotta Maki, Nagase Aki, Kozawa Junji, Maeda Norikazu, Otsuki Michio, Matsuoka Takaaki, Iwahashi Hiromi, Shimomura Iichiro, Murayama Norihito, Watanabe Hiroshi, Ikeda Manabu, Mizuta Ichiro, Kudo Takashi |
| 発行年月 | 2022/05 |
| 概要 | BACKGROUND:Patients with diabetes are at a higher risk for cognitive decline. Thus, biomarkers that can provide early and simple detection of cognitive decline are required. Neurofilament light chain (NfL) is a cytoskeletal protein that constitutes neural axons. Plasma NfL levels are elevated when neurodegeneration occurs. Here, we investigated whether plasma NfL levels were associated with cognitive decline in patients with type 2 diabetes.METHOD:This study included 183 patients with type 2 diabetes who visited Osaka University Hospital. All participants were tested for cognitive function using the Mini-Mental State Examination (MMSE) and the Rivermead Behavioural Memory Test (RBMT). NfL levels were analysed in the plasma and the relationship between NfL and cognitive function was examined.RESULTS:Lower RBMT-standardized profile scores (SPS) or MMSE scores correlated with higher plasma NfL levels (one-way analysis of variance: MMSE, P = 0.0237; RBMT-SPS, P = 0.0001). Furthermore, plasma NfL levels (β = -0.34, P = 0.0005) and age (β = -0.19, P = 0.016) were significantly associated with the RBMT score after multivariable regression adjustment.CONCLUSIONS:Plasma NfL levels were correlated with mild cognitive decline which is detected by the RBMT but not the MMSE in patients with type 2 diabetes. This suggests that plasma NfL levels may provide a valuable clinical tool for identifying mild cognitive decline in patients with diabetes. |
| DOI | 10.1111/psyg.12819 |
| PMID | 35279914 |