Michio Otsuki
Department School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine Position Professor and Division head |
|
Article types | Original article |
Language | English |
Peer review | Peer reviewed |
Title | Effects of pitavastatin on serum lipids and high sensitivity C-reactive protein in type 2 diabetic patients |
Journal | Formal name:Journal of atherosclerosis and thrombosis Abbreviation:J Atheroscler Thromb ISSN code:18803873 (Electronic)13403478 (Linking) |
Domestic / Foregin | Domestic |
Volume, Issue, Page | 16(5),pp.546-552 |
Author and coauthor | Motomura, T. Okamoto, M. Kitamura, T. Yamamoto, H. Otsuki, M. Asanuma, N. Takagi, M. Kurebayashi, S. Hashimoto, K. Sumitani, S. Saito, H. Kouhara, H. Nshii, K. Nakao, M. Koga, M. Sato, B. Morimoto, Y. Kasayama, S. |
Publication date | 2009 |
Summary | AIM: Previous studies have been inconsistent results about the effects of statins on serum triglyceride (TG), high-density lipoprotein cholesterol (HDL-C) and high sensitivity C-reactiveprotein (hsCRP) levels. We therefore investigated the effects of pitavastatin on serum lipid profiles and hsCRP levels in patients with type 2 diabetes mellitus. METHODS: The study population was 65 Japanese type 2 diabetic patients who had been administered 2 mg daily of pitavastatin and completed a 6-month follow-up. Serum lipids and hsCRP were measured before and after treatment for 1, 3, and 6 months. RESULTS: Total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and TG had significantly reduced after 1 month and remained reduced for 6 months, while HDL-C levels had significantly increased after 1 month and remained at the higher level for 6 months. Baseline median levels of hsCRP were 0.49 mg/L and showed a significant reduction to 0.37 mg/L at 6 months'treatment (p<0.001). Six-month changes in hsCRP levels were not associated with those in TC, LDL-C, HDL-C or TG. CONCLUSION: Pitavastatin improved serum lipid profiles and reduced serum hsCRP levels in type 2 diabetic patients with relatively low inflammation. The effect on hsCRP was not related to the effects on serum lipid profiles. |
DOI | 10.5551/jat.992. |
Document No. | 19729863 |