Michio Otsuki    Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine    Position   Professor and Division head
Article types	Original article
Language	English
Peer review	Peer reviewed
Title	Adiponectin regulates vascular endothelial growth factor-C expression in macrophages via Syk-ERK pathway
Journal	Formal name：PloS one Abbreviation：PLoS One ISSN code：19326203 (Electronic)19326203 (Linking)
Domestic / Foregin	Foregin
Volume, Issue, Page	8(2),pp.e56071
Author and coauthor	Hu, D. Fukuhara, A. Miyata, Y. Yokoyama, C. Otsuki, M. Kihara, S. Shimomura, I.
Publication date	2013
Summary	Adiponectin is exclusively expressed in adipose tissues and exhibits protective effects against cardiovascular and metabolic diseases. It enhances AMP-activated kinase (AMPK) and peroxisome proliferator-activated receptor alpha (PPARalpha) signaling in the liver and skeletal muscles, however, its signaling pathways in macrophages remain to be elucidated. Here, we show that adiponectin upregulated the expression of vascular endothelial growth factor (VEGF)-C, and induced phosphorylation of extracellular signal-regulated kinase (ERK) in macrophages. Inhibition of Syk abrogated adiponectin-induced VEGF-C expression and ERK phosphorylation. Furthermore, inhibition of ERK blocked the induction of VEGF-C gene. Inhibition of Syk, but not that of ERK, abrogated adiponectin-induced expression of cyclooxygenase (COX)-2, tissue inhibitor of metalloproteinase (TIMP)-1, and interleukin (IL)-6. These results indicate that adiponectin regulates VEGF-C expression via Syk-ERK pathway in macrophages.
DOI	10.1371/journal.pone.0056071
Document No.	23424645