Michio Otsuki    Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine    Position   Professor and Division head
Article types	Original article
Language	English
Peer review	Peer reviewed
Title	Effects of growth hormone excess on glycated albumin concentrations: Analysis in acromegalic patients
Journal	Formal name：Clinica chimica acta; international journal of clinical chemistry Abbreviation：Clin Chim Acta ISSN code：00098981/18733492
Domestic / Foregin	Foregin
Volume, Issue, Page	440,pp.93-96
Author and coauthor	Tamada, D. Otsuki, M. Kitamura, T. Oshino, S. Saitoh, Y. Shimomura, I. Koga, M.
Authorship	2nd author
Publication date	2015
Summary	BACKGROUND: Glycated albumin (GA) does not reflect glycemic control in patients with disorders of albumin metabolism. In the present study, we examined GA concentrations in acromegalic patients with growth hormone (GH) excess. METHODS: We studied the hormonal status of 29 acromegalic patients (10 patients had diabetes mellitus and the remaining 19 patients were non-diabetic), 20 patients with type 2 diabetes mellitus and 38 non-diabetic subjects matched for age, sex and body mass index. RESULTS: Serum GA concentrations, but not those of fasting plasma glucose, 2-h post-load plasma glucose and HbA1c, were significantly higher in non-diabeticacromegalic patients compared with non-diabetic control subjects. Serum GA concentrations, but not those of fasting plasma glucose and HbA1c, were significantly higher in diabetic acromegalic patients compared with patients with type 2 diabetes mellitus. CONCLUSIONS: This is the first report describing higher GA concentrations in acromegalic patients relative to plasma glucose concentrations. Special care should be taken when evaluating glycemic control using GA because acromegaly is frequently complicated with diabetes mellitus.
DOI	10.1016/j.cca.2014.11.009
Document No.	25447699