オオツキ　ミチオ   Michio Otsuki   大月　道夫    所属   医学部 医学科（東京女子医科大学病院）    職種   教授・基幹分野長
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Effects of growth hormone excess on glycated albumin concentrations: Analysis in acromegalic patients
掲載誌名	正式名：Clinica chimica acta; international journal of clinical chemistry 略　 称：Clin Chim Acta ISSNコード：00098981/18733492
掲載区分	国外
巻・号・頁	440,pp.93-96
著者・共著者	Tamada, D. Otsuki, M. Kitamura, T. Oshino, S. Saitoh, Y. Shimomura, I. Koga, M.
担当区分	2nd著者
発行年月	2015
概要	BACKGROUND: Glycated albumin (GA) does not reflect glycemic control in patients with disorders of albumin metabolism. In the present study, we examined GA concentrations in acromegalic patients with growth hormone (GH) excess. METHODS: We studied the hormonal status of 29 acromegalic patients (10 patients had diabetes mellitus and the remaining 19 patients were non-diabetic), 20 patients with type 2 diabetes mellitus and 38 non-diabetic subjects matched for age, sex and body mass index. RESULTS: Serum GA concentrations, but not those of fasting plasma glucose, 2-h post-load plasma glucose and HbA1c, were significantly higher in non-diabeticacromegalic patients compared with non-diabetic control subjects. Serum GA concentrations, but not those of fasting plasma glucose and HbA1c, were significantly higher in diabetic acromegalic patients compared with patients with type 2 diabetes mellitus. CONCLUSIONS: This is the first report describing higher GA concentrations in acromegalic patients relative to plasma glucose concentrations. Special care should be taken when evaluating glycemic control using GA because acromegaly is frequently complicated with diabetes mellitus.
DOI	10.1016/j.cca.2014.11.009
文献番号	25447699