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Michio Otsuki
Department School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine Position Professor and Division head |
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| Article types | Case report |
| Language | English |
| Peer review | Peer reviewed |
| Title | Multiple Gouty Tophi with Bone Erosion and Destruction: A Report of an Early-onset Case in an Obese Patient |
| Journal | Formal name：Internal Medicine Abbreviation：Intern Med ISSN code：09182918 |
| Domestic / Foregin | Domestic |
| Volume, Issue, Page | 56(9),pp.1071-1077 |
| Author and coauthor | D. Hayashi R Yamaoka, M. Nishizawa, H. Fukuda, S. Fujishima, Y. Kimura, T. Kozawa, J. Kita, S. Matsuoka, T. A. Otsuki, M. Imagawa, A. Ichida, K. Taniguchi, A. Maeda, N. Funahashi, T. Shimomura, I. |
| Publication date | 2017 |
| Summary | A 27 year-old severely obese man (BMI, 35.1) had hyperuricemia and multiple gouty tophi with bone erosion and destruction, resulting in gait disturbance for 6 years after the early onset of gout at 21 years of age. His hyperuricemia was associated with hyperinsulinemia in obesity and a genetic variant of the ABCG2 gene. In addition, multiple gouty tophi with bone erosion and destruction might have been caused by hypoadiponectinemia and the elevation of the patient's pro-inflammatory cytokine (IL-1beta) level with the accumulation of visceral fat. In this case, bone and Ga-67 scintigraphy were useful for detecting the location and magnitude of gouty tophi. |
| DOI | 10.2169/internalmedicine.56.7923 |
| Document No. | 28458315 |