オオツキ ミチオ
Michio Otsuki
大月 道夫 所属 医学部 医学科(東京女子医科大学病院) 職種 教授・基幹分野長 |
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論文種別 | 症例報告 |
言語種別 | 英語 |
査読の有無 | 査読あり |
表題 | Multiple Gouty Tophi with Bone Erosion and Destruction: A Report of an Early-onset Case in an Obese Patient |
掲載誌名 | 正式名:Internal Medicine 略 称:Intern Med ISSNコード:09182918 |
掲載区分 | 国内 |
巻・号・頁 | 56(9),pp.1071-1077 |
著者・共著者 | D. Hayashi R Yamaoka, M. Nishizawa, H. Fukuda, S. Fujishima, Y. Kimura, T. Kozawa, J. Kita, S. Matsuoka, T. A. Otsuki, M. Imagawa, A. Ichida, K. Taniguchi, A. Maeda, N. Funahashi, T. Shimomura, I. |
発行年月 | 2017 |
概要 | A 27 year-old severely obese man (BMI, 35.1) had hyperuricemia and multiple gouty tophi with bone erosion and destruction, resulting in gait disturbance for 6 years after the early onset of gout at 21 years of age. His hyperuricemia was associated with hyperinsulinemia in obesity and a genetic variant of the ABCG2 gene. In addition, multiple gouty tophi with bone erosion and destruction might have been caused by hypoadiponectinemia and the elevation of the patient's pro-inflammatory cytokine (IL-1beta) level with the accumulation of visceral fat. In this case, bone and Ga-67 scintigraphy were useful for detecting the location and magnitude of gouty tophi. |
DOI | 10.2169/internalmedicine.56.7923 |
文献番号 | 28458315 |