Michio Otsuki    Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine    Position   Professor and Division head
Article types	Original article
Language	English
Peer review	Peer reviewed
Title	Impact of MR on mature adipocytes in high-fat/high-sucrose diet-induced obesity
Journal	Formal name：The Journal of endocrinology Abbreviation：J Endocrinol ISSN code：00220795
Domestic / Foregin	Foregin
Volume, Issue, Page	239(1),pp.63-71
Author and coauthor	Hayakawa, T. Minemura, T. Onodera, T. Shin, J. Okuno, Y. Fukuhara, A. Otsuki, M. Shimomura, I.
Publication date	2018
Summary	Active glucocorticoid levels are elevated in the adipose tissue of obesity due tothe enzyme 11beta-hydroxysteroid dehydrogenase type 1. Glucocorticoids can bind and activate both glucocorticoid receptor (GR) and mineralocorticoid receptor (MR), and pharmacological blockades of MR prevents high-fat diet-induced obesity and glucose intolerance. To determine the significance of MR in adipocytes, we generated adipocyte-specific MR knockout mice (AdipoMR-KO) and fed them high-fat/high-sucrose diet. We found that adipocyte-specific deletion of MR did not affect the body weight, fat weight, glucose tolerance, or insulin sensitivity. While liver weight was slightly reduced in AdipoMR-KO, there were no significant differences in the mRNA expression levels of genes associated with lipogenesis, lipolysis, adipocytokines, and oxidative stress in adipose tissues between the control and AdipoMR-KO mice. The results indicated that MR in mature adipocytes plays a minor role in the regulation of insulin resistance and inflammation in high-fat/high-sucrose diet-induced obese mice.
DOI	10.1530/joe-18-0026
Document No.	30049823