Michio Otsuki    Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine    Position   Professor and Division head
Article types	Case report
Language	English
Peer review	Peer reviewed
Title	Asymptomatic Pontine Lesion and Diabetic Amyotrophy after Rapid Improvement of Poor Glycemic Control in a Patient with Type 1 Diabetes
Journal	Formal name：Internal Medicine Abbreviation：Intern Med ISSN code：09182918
Domestic / Foregin	Domestic
Volume, Issue, Page	58(23),pp.3433-3439
Author and coauthor	Shimizu, Y. Kozawa, J. Hayakawa, T. Sakai, Y. Kimura, T. Kitamura, T. Murase, S. Tanaka, H. Maeda, N. Otsuki, M. Matsuoka, T. Mochizuki, H. Iwahashi, H. Shimomura, I.
Publication date	2019
Summary	We herein report a 28-year-old woman with type 1 diabetes with an asymptomatic pontine lesion and diabetic amyotrophy. She had suffered from diabetes from 10 years old. Treatment in a hospital reduced the hemoglobin A1c level from 14.2% to 7.2% for approximately 2 months. She suffered from acute-onset pain and weakness of the lower limb muscles without central nervous system manifestations. Magnetic resonance imaging showed high-intensity lesions at the brainstem and lower limb muscles on T2-weighted images. These findings and symptoms gradually resolved. Rapid treatment of poor glycemic control might increase the risk of asymptomatic pontine lesions and diabetic amyotrophy.
DOI	10.2169/internalmedicine.2835-19
Document No.	31391398