Michio Otsuki    Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine    Position   Professor and Division head
Article types	Case report
Language	English
Peer review	Peer reviewed
Title	Marked Hypergastrinemia with G-cell Hyperplasia in Two Autoimmune Gastritis Patients
Journal	Formal name：Internal Medicine Abbreviation：Intern Med ISSN code：09182918
Domestic / Foregin	Domestic
Volume, Issue, Page	59(6),pp.799-803
Author and coauthor	Watanabe, H. Yoneda, S. Motoyama, Y. Mukai, K. Okuno, Y. Kozawa, J. Nishizawa, H. Maeda, N. Otsuki, M. Matsuoka, T. A. Morii, E. Iwahashi, H. Shimomura, I.
Publication date	2019
Summary	Gastrin regulates gastric acid secretion, and gastrin secretion itself is regulated by the negative feedback system of gastric acidity. Autoimmune gastritis (AG) is a disease where parietal cells are destroyed, resulting in decreased acid production and an elevated serum gastrin level. We herein report 2 AG cases with marked hypergastrinemia (>5,000 pg/mL). In both cases, 24-h gastric pH monitoring showed no time when gastric pH was<2, and immunohistochemistry revealed more than 140 gastrin-positive cells per linear millimeter at the antral mucosa. This is the first report to confirm the relationship between marked hypergastrinemia and G-cell hyperplasia with AG.
DOI	10.2169/internalmedicine.3009-19
Document No.	31787690