オオツキ　ミチオ   Michio Otsuki   大月　道夫    所属   医学部 医学科（東京女子医科大学病院）    職種   教授・基幹分野長
論文種別	症例報告
言語種別	英語
査読の有無	査読あり
表題	Marked Hypergastrinemia with G-cell Hyperplasia in Two Autoimmune Gastritis Patients
掲載誌名	正式名：Internal Medicine 略　 称：Intern Med ISSNコード：09182918
掲載区分	国内
巻・号・頁	59(6),pp.799-803
著者・共著者	Watanabe, H. Yoneda, S. Motoyama, Y. Mukai, K. Okuno, Y. Kozawa, J. Nishizawa, H. Maeda, N. Otsuki, M. Matsuoka, T. A. Morii, E. Iwahashi, H. Shimomura, I.
発行年月	2019
概要	Gastrin regulates gastric acid secretion, and gastrin secretion itself is regulated by the negative feedback system of gastric acidity. Autoimmune gastritis (AG) is a disease where parietal cells are destroyed, resulting in decreased acid production and an elevated serum gastrin level. We herein report 2 AG cases with marked hypergastrinemia (>5,000 pg/mL). In both cases, 24-h gastric pH monitoring showed no time when gastric pH was<2, and immunohistochemistry revealed more than 140 gastrin-positive cells per linear millimeter at the antral mucosa. This is the first report to confirm the relationship between marked hypergastrinemia and G-cell hyperplasia with AG.
DOI	10.2169/internalmedicine.3009-19
文献番号	31787690