Michio Otsuki
   Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine
   Position   Professor and Division head
Article types Original article
Language English
Peer review Peer reviewed
Title Association of abdominal obesity with crossing capillaries in the finger nailfold in type 2 diabetes mellitus
Journal Formal name：Diabetology international.
Abbreviation：Diabetol Int
ISSN code：21901678/21901686
Domestic / ForeginDomestic
Volume, Issue, Page 12(3),pp.260-267
Author and coauthor Shikama, M. Sonoda, N. Morimoto, A. Suga, S. Tajima, T. Kozawa, J. Maeda, N. Otsuki, M. Matsuoka, T. A. Shimomura, I. Ohno, Y.
Publication date 2021
Summary Aim: Increased crossing of finger nailfold capillaries could be a novel visual marker of early microvascular damage among type 2 diabetes mellitus patients. Although abdominal obesity is an important driver of early microvascular damage, its association with an increase in the percentage of crossing capillaries remains uncertain. We investigated the association between abdominal obesity and an increase in the percentage of crossing capillaries in the finger nailfold in patients with type 2 diabetes mellitus. Methods: This cross-sectional study enrolled 123 type 2 diabetes mellitus patients (age 40-75 years) who visited the outpatient diabetic clinic at Osaka University Hospital between May and October 2019. Abdominal obesity was defined as a waist circumference>/= 90 cm in women and>/= 85 cm in men. Capillary morphology was assessed by nailfold capillaroscopy based on the simple capillaroscopic definitions of the European League Against Rheumatism Study Group. The association between abdominal obesity and a high percentage of crossing capillaries in the finger nailfold (defined as the highest tertile of crossing capillaries) was analyzed using multivariable logistic regression. Results: After adjusting for age, sex, smoking status, regular exercise, duration of diabetes, glycated hemoglobin, hypertension, and dyslipidemia, abdominal obesity was significantly associated with a high percentage of crossing capillaries (multivariable-adjusted odds ratios [95% confidence interval]= 2.70 [1.05-6.90], p = 0.038). Conclusions: Abdominal obesity may play an important role in the increase in the percentage of crossing capillaries in the finger nailfold in patients with type 2 diabetes mellitus.
DOI 10.1007/s13340-020-00480-4
Document No. 34150434