Michio Otsuki    Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine    Position   Professor and Division head
Article types	Case report
Language	English
Peer review	Peer reviewed
Title	A patient with acromegaly who showed remarkable improvement of hyperglycemia after treatment with octreotide
Journal	Formal name：Internal medicine Abbreviation：Intern Med ISSN code：09182918 (Print)09182918 (Linking)
Domestic / Foregin	Domestic
Volume, Issue, Page	36(5),pp.345-350
Author and coauthor	Hirose, T. Kuroda, T. Otsuki, M. Takagi, M. Yamamoto, H. Motomura, T. Kurebayashi, S. Miyashita, Y. Koga, M. Arita, N. Hayakawa, T. Kishimoto, T. Kasayama, S.
Publication date	1997
Summary	A case with diabetes mellitus associated with growth hormone (GH)-producing pituitary adenoma is described. A 56-year-old woman who had been treated for diabetes mellitus for 3 years, was admitted for the treatment of hyperglycemia. She showed a few acromegalic features and her plasma GH level was 146 +/- 16 ng/ml. After improvement of plasma glucose level by insulin injection, octreotide therapy (100 micrograms/8 hours) was started. Seven days after the initiation of octreotide therapy, the fasting plasma glucose level was almost normalized without insulin injection. After the octreotide treatment, urinary C-peptide excretion was significantly decreased and the plasma GH level became within normal range. In this case, octreotide appears to have improved the insulin sensitivity by reducing the plasma GH level.
DOI	10.2169/internalmedicine.36.345.
Document No.	9213172