オオツキ　ミチオ   Michio Otsuki   大月　道夫    所属   医学部 医学科（東京女子医科大学病院）    職種   教授・基幹分野長
論文種別	症例報告
言語種別	英語
査読の有無	査読あり
表題	A patient with acromegaly who showed remarkable improvement of hyperglycemia after treatment with octreotide
掲載誌名	正式名：Internal medicine 略　 称：Intern Med ISSNコード：09182918 (Print)09182918 (Linking)
掲載区分	国内
巻・号・頁	36(5),pp.345-350
著者・共著者	Hirose, T. Kuroda, T. Otsuki, M. Takagi, M. Yamamoto, H. Motomura, T. Kurebayashi, S. Miyashita, Y. Koga, M. Arita, N. Hayakawa, T. Kishimoto, T. Kasayama, S.
発行年月	1997
概要	A case with diabetes mellitus associated with growth hormone (GH)-producing pituitary adenoma is described. A 56-year-old woman who had been treated for diabetes mellitus for 3 years, was admitted for the treatment of hyperglycemia. She showed a few acromegalic features and her plasma GH level was 146 +/- 16 ng/ml. After improvement of plasma glucose level by insulin injection, octreotide therapy (100 micrograms/8 hours) was started. Seven days after the initiation of octreotide therapy, the fasting plasma glucose level was almost normalized without insulin injection. After the octreotide treatment, urinary C-peptide excretion was significantly decreased and the plasma GH level became within normal range. In this case, octreotide appears to have improved the insulin sensitivity by reducing the plasma GH level.
DOI	10.2169/internalmedicine.36.345.
文献番号	9213172