Michio Otsuki
   Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine
   Position   Professor and Division head
Article types Original article
Language English
Peer review Peer reviewed
Title Relationship between circulating vascular cell adhesion molecule-1 and microvascular complications in type 2 diabetes mellitus
Journal Formal name：Diabetic medicine : a journal of the British Diabetic Association
Abbreviation：Diabet Med
ISSN code：07423071 (Print)07423071 (Linking)
Domestic / ForeginForegin
Volume, Issue, Page 15(8),pp.661-667
Author and coauthor Koga, M. Otsuki, M. Kubo, M. Hashimoto, J. Kasayama, S.
Authorship 2nd author
Publication date 1998
Summary The soluble form of the vascular cell adhesion molecule-1 (VCAM-1) is detectable in human sera and is elevated in diabetic patients, with unknown clinical significance. In the present study, the relationship between serum soluble VCAM-1 and diabetic microvascular complications (retinopathy, nephropathy, and neuropathy) was evaluated in 95 Japanese patients with Type 2 diabetes mellitus (DM). Serum soluble VCAM-1 concentration was higher in patients with more advanced stages of retinopathy as well as nephropathy. There was a significant correlation between soluble VCAM-1 and log10 (urinary albumin excretion) in 69 patients with normal serum creatinine levels (r = 0.51, p<0.0001) and a significant correlation between soluble VCAM-1 and log10 (serum creatinine) in all the patients (r = 0.83, p<0.0001). Soluble VCAM-1 concentration was also elevated in patients with neuropathy. There was a significant correlation between soluble VCAM-1 concentration and the number of microvascular complications (r = 0.59, p<0.0001). However, multivariate regression analysis revealed that only diabetic nephropathy, was associated with the soluble VCAM-1 concentration. The elevation of circulating VCAM-1 level in diabetic nephropathy may result from underlying systemic endothelial dysfunction, increased VCAM-1 production in damaged renal tubular or glomerular epithelial cells and/or decreased renal clearance of this molecule, depending on the stage of nephropathy.
DOI 10.1002/(SICI)1096-9136(199808)15:8<661::AID-DIA645>3.0.CO;2-G
Document No. 9702469