Michio Otsuki
   Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine
   Position   Professor and Division head
Article types Case report
Language English
Peer review Peer reviewed
Title A case of hypogonadotropic hypogonadism caused by opioid treatment for nonmalignant chronic pain
Journal Formal name:Case reports in medicine
Abbreviation:Case Rep Med
ISSN code:16879635 (Electronic)
Domestic / ForeginForegin
Volume, Issue, Page 2012,pp.740603
Author and coauthor Tabuchi, Y. Yasuda, T. Kaneto, H. Kitamura, T. Kozawa, J. Otsuki, M. Imagawa, A. Nakae, A. Matsuda, Y. Uematsu, H. Mashimo, T. Shibata, M. Shimomura, I.
Publication date 2012
Summary We report a case of 42-year-old male patient with hypogonadotropic hypogonadism. He suffered from general fatigue and erectile dysfunction after the treatment with transdermal fentanyl for chronic pain by traffic injury. Endocrine examinations and hormone stimulating tests showed that he had hypogonadotropic hypogonadism. Brain magnetic resonance imaging (MRI) showed no abnormal findings, and he had no past history of accounting for acquired hypogonadotropic hypogonadism. Therefore, his hypogonadism was diagnosed to be caused by opioid treatment. Although opioid-induced endocrine dysfunctions are not widely recognized, this case suggests that we should consider the possibility of endocrine dysfunctions in patients with opioid treatment.
DOI 10.1155/2012/740603
Document No. 23326276