Michio Otsuki    Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine    Position   Professor and Division head
Article types	Original article
Language	English
Peer review	Peer reviewed
Title	Rapid decline in bone turnover markers but not bone mineral density in acromegalic patients after transsphenoidal surgery
Journal	Formal name：Endocrine Journal Abbreviation：Endocr J ISSN code：09188959
Domestic / Foregin	Domestic
Volume, Issue, Page	61(3),pp.231-237
Author and coauthor	Tamada, D. Kitamura, T. Onodera, T. Tabuchi, Y. Fukuhara, A. Oshino, S. Saitoh, Y. Hamasaki, T. Otsuki, M. Shimomura, I.
Authorship	Corresponding author
Publication date	2014
Summary	Growth hormone (GH) and insulin-like growth factor-I (IGF-I) play important roles in maintaining bone metabolism and bone mineral density (BMD) in adulthood, in addition to stimulating longitudinal bone growth in childhood. However, information on the effect of GH excess on bone metabolism and BMD is incomplete and requires further analysis. The aim of this study is to clarify the effect of rapid decline in GH levels after transsphenoidal surgery (TSS) on bone metabolism in acromegalic patients. In this prospective study, 22 patients (11 males and 11 females) with active acromegaly underwent TSS. Bone formation marker (serum bone alkaline phosphatase: BAP), bone resorption marker (urinary type I collagen cross-linked N-telopeptide: urinary NTx) and BMD were measured before and at 3 and 12 months after TSS. BAP was significantly decreased at 12 months after TSS, but not at 3 months. Urinary NTx was significantly decreased at 3 and 12 months after TSS. BMD did not change after TSS. In conclusion, the rapid fall in GH level after TSS had no effect on BMD for up to 12 months after TSS despite the decrease in markers of bone formation and resorption.
DOI	10.1507/endocrj.ej13-0387
Document No.	24304925