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Michio Otsuki
Department School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine Position Professor and Division head |
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| Article types | Case report |
| Language | English |
| Peer review | Peer reviewed |
| Title | Suppression Failure of Cortisol Secretion by Dexamethasone May Occur in Glucagon-like Peptide-1 Receptor Agonist-treated Patients with Diabetic Autonomic Neuropathy |
| Journal | Formal name：Internal Medicine Abbreviation：Intern Med ISSN code：09182918 |
| Domestic / Foregin | Domestic |
| Volume, Issue, Page | 58(7),pp.949-953 |
| Author and coauthor | Nagai, Y. Mukai, K. Otsuki, M. Kimura, T. Kozawa, J. Nishizawa, H. Maeda, N. Matsuoka, T. A. Iwahashi, H. Imagawa, A. Shimomura, I. |
| Authorship | Corresponding author |
| Publication date | 2018 |
| Summary | Two diabetic women (case 1, 75 years old; case 2, 49 years old) being treated with GLP-1 receptor agonists (GLP-1 RAs) showed no suppression of cortisol secretion on a dexamethasone suppression test (DST). However, its secretion was suppressed after switching from GLP-1 RAs to insulin. We also checked the cortisol secretion by a DST in five consecutive inpatients (case 3-7) being treated with GLP-1 RAs. The coefficients of R-R interval variation at rest and during deep breathing were lower in the two false-positive cases (case 1 and 2) than in the five true-negative cases (case 3-6). GLP-1 RAs can be switched to insulin in order to eliminate the slow absorption effect of dexamethasone by GLP-1 RAs if a DST is planned in diabetic patients receiving GLP-1 RAs. |
| DOI | 10.2169/internalmedicine.1585-18 |
| Document No. | 30568127 |