Michio Otsuki    Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine    Position   Professor and Division head
Article types	Original article
Language	English
Peer review	Peer reviewed
Title	Renal function is associated with blood neurofilament light chain level in older adults
Journal	Formal name：Scientific Reports ISSN code：20452322
Domestic / Foregin	Foregin
Volume, Issue, Page	10(1),pp.20350
Author and coauthor	Akamine, S. Marutani, N. Kanayama, D. Gotoh, S. Maruyama, R. Yanagida, K. Sakagami, Y. Mori, K. Adachi, H. Kozawa, J. Maeda, N. Otsuki, M. Matsuoka, T. Iwahashi, H. Shimomura, I. Ikeda, M. Kudo, T.
Publication date	2020
Summary	Neurofilament light chain (NfL) is a novel biomarker of neurodegenerative diseases. It is detectable in the peripheral blood, allowing low-invasive assessment of early signs of neurodegeneration. The level of NfL gradually increases with age; however, what other factors affect it remains unclear. The present study examined the association between blood NfL level and renal function among healthy participants undergoing a health check (n = 43, serum NfL) and patients with diabetes mellitus (n = 188, plasma NfL). All participants were 60 years of age or older; none were diagnosed with dementia. In each group, levels of blood NfL and serum creatinine significantly correlated (coefficient r = 0.50, 0.56). These associations remained statistically significant even after adjustment for age, sex, and body mass index. These findings indicate that blood NfL level might be partially affected by renal function. We recommend measuring renal function for a more precise evaluation of neuroaxonal damage, in particular, among older adults.
DOI	10.1038/s41598-020-76990-7
Document No.	33230211