オオツキ　ミチオ   Michio Otsuki   大月　道夫    所属   医学部 医学科（東京女子医科大学病院）    職種   教授・基幹分野長
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Renal function is associated with blood neurofilament light chain level in older adults
掲載誌名	正式名：Scientific Reports ISSNコード：20452322
掲載区分	国外
巻・号・頁	10(1),pp.20350
著者・共著者	Akamine, S. Marutani, N. Kanayama, D. Gotoh, S. Maruyama, R. Yanagida, K. Sakagami, Y. Mori, K. Adachi, H. Kozawa, J. Maeda, N. Otsuki, M. Matsuoka, T. Iwahashi, H. Shimomura, I. Ikeda, M. Kudo, T.
発行年月	2020
概要	Neurofilament light chain (NfL) is a novel biomarker of neurodegenerative diseases. It is detectable in the peripheral blood, allowing low-invasive assessment of early signs of neurodegeneration. The level of NfL gradually increases with age; however, what other factors affect it remains unclear. The present study examined the association between blood NfL level and renal function among healthy participants undergoing a health check (n = 43, serum NfL) and patients with diabetes mellitus (n = 188, plasma NfL). All participants were 60 years of age or older; none were diagnosed with dementia. In each group, levels of blood NfL and serum creatinine significantly correlated (coefficient r = 0.50, 0.56). These associations remained statistically significant even after adjustment for age, sex, and body mass index. These findings indicate that blood NfL level might be partially affected by renal function. We recommend measuring renal function for a more precise evaluation of neuroaxonal damage, in particular, among older adults.
DOI	10.1038/s41598-020-76990-7
文献番号	33230211