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神崎 正人
Department School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine Position Professor and Division head |
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| Article types | Original article |
| Language | English |
| Peer review | Peer reviewed |
| Title | Thoracoscopic cell sheet transplantation with a novel device |
| Journal | Formal name：Journal of Tissue Engineering and Regenerative Medicine Abbreviation：J Tissue Eng Regen Med ISSN code：19327005 |
| Domestic / Foregin | Foregin |
| Volume, Issue, Page | 3(4),pp.255-259 |
| Author and coauthor | MAEDA Masanori†,YAMATO Masayuki, KANZAKI Masato, ISEKI Hiroshi, OKANO Teruo |
| Publication date | 2009/06 |
| Summary | Regenerative medicine with transplantable cell sheets fabricated on temperature-responsive culture surfaces has been successfully achieved in clinical applications, including skin and cornea treatment. Previously, we reported that transplantation of fibroblast cell sheets to wounded lung had big advantages for sealing intraoperative air leaks compared with conventional materials. Here, we report a novel device for minimally invasive transplantation of cell sheets in endoscopic surgery, such as video-assisted thoracoscopic surgery (VATS). The novel device was designed with a computer-aided design (CAD) system, and the three-dimensional (3D) data were transferred to a 3D printer. With this rapid prototyping system, the cell sheet transplantation device was fabricated using a commercially available photopolymer approved for clinical use. Square cell sheets (24 x 24 mm) were successfully transplanted onto wound sites of porcine lung placed in a human body model, with the device inserted through a 12 mm port. Such a device would enable less invasive transplantation of cell sheets onto a wide variety of internal organs. |
| DOI | 10.1002/term.161. |
| PMID | 19382117 |