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Goro Honda
Department School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine Position Professor and Division head |
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| Article types | Original article |
| Language | English |
| Peer review | Non peer reviewed |
| Title | Validation study of the JSHBPS nomogram for patients with colorectal liver metastases who underwent hepatic resection in the recent era - a nationwide survey in Japan |
| Journal | Formal name：Journal of hepato-biliary-pancreatic sciences Abbreviation：J Hepatobiliary Pancreat Sci ISSN code：18686982/18686974 |
| Domestic / Foregin | Domestic |
| Volume, Issue, Page | 30(5),pp.591-601 |
| Author and coauthor | Beppu Toru, Yamamura Kensuke, Sakamoto Katsunori, Honda Goro, Kobayashi Shin, Endo Itaru, Hasegawa Kiyoshi, Kotake Kenjiro, Itabashi Michio, Hashiguchi Yojiro, Kotera Yoshihito, Yamaguchi Tatsuro, Natsume Soichiro, Tabuchi Ken, Kobayashi Hirotoshi, Yamaguchi Kensei, Morita Satoshi, Kikuchi Ken, Miyazaki Masaru, Sugihara Kenichi, Yamamoto Masakazu, Takahashi Keiichi, |
| Publication date | 2023/05 |
| Summary | BACKGROUND:The Japanese Society of Hepato-Biliary-Pancreatic Surgery (JSHBPS) nomogram was developed to predict disease-free survival in patients with colorectal liver metastases (CRLM) undergoing upfront hepatectomy. However, the utility of the nomogram in patients with resected CRLM remains unknown in the current situation in which treatment strategies are changing with advances in drugs.METHODS:Patients in the initial nomogram cohort (n = 727) and validation cohort (n = 2225) were divided into the upfront hepatectomy and preoperative chemotherapy groups. The nomogram was validated by measuring calibration and discrimination in the two cohorts. Calibration curves were plotted, and survival probabilities were compared. Finally, to quantify the discrimination power, we estimated the concordance index (C-index).RESULTS:In the upfront hepatectomy group, the C-index was 0.63, the suitable cutoff value of the Beppu score was 7, and adjuvant chemotherapy was significantly effective limited to high-risk patients (Beppu score ≥7). The C-index was 0.56 in the preoperative chemotherapy group.CONCLUSIONS:The JSHBPS nomogram remains beneficial for patients undergoing upfront hepatectomy in the recent era but is less effective for patients undergoing hepatectomy after chemotherapy. Patients with a Beppu score ≥7 showed high-risk recurrence, and adjuvant chemotherapy should be recommended for these patients. |
| DOI | 10.1002/jhbp.1256 |
| PMID | 36285571 |