OGAWA Shimpei
   Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine
   Position   Associate Professor
Article types Original article
Language English
Peer review Non peer reviewed
Title Superior prognosis stratification for stage III colon cancer using log odds of positive lymph nodes (LODDS) compared to TNM stage classification: the Japanese study group for postoperative follow-up of colorectal cancer.
Journal Formal name：Oncotarget
Abbreviation：Oncotarget
ISSN code：19492553/19492553
Domestic / ForeginForegin
Volume, Issue, Page 11(33),pp.3144-3152
Author and coauthor OGAWA Shimpei†, ITABASHIi Michio, BAMBA Yoshiko, YAMAMOTO Masakazu, SUGIHARA Kenichi
Authorship Lead author,Corresponding author
Publication date 2020/08
Summary OBJECTIVES:The aim of this study is to examine whether prognosis stratification in staging of Stage III colon cancer using T factor and log odds of positive lymph nodes (LODDS) categories is superior to that of the TNM staging system.MATERIALS AND METHODS:The subjects were 5,919 patients with Stage III colon cancer who underwent curative resection at 24 Japanese institutions. Univariate analysis of LODDS categories and clinicopathologic factors was conducted using a Cox proportional hazards regression model for cancer-specific survival (CSS). Independent prognostic factors for CSS were extracted in multivariate analysis using factors with significance in univariate analysis. Effect sizes of risk factors for CSS were compared using the LogWorth statistic. Combinations of T factor and LODDS categories were used to create L-stage subgroups A, B and C. Stratification of prognosis with L-stage and TNM was compared using the Akaike information criterion (AIC).RESULTS:In multivariate analysis, LODDS was identified as an independent prognostic factor, together with age, maximum tumor diameter, histopathological grade, L, V, pT, and pN. The LogWorth of LODDS was 17.149, which was the second highest after pT (31.562), and that of pN was 7.434. The 5-year CSS was 96.5%, 88.5%, and 66.6% in TNM stages IIIA, IIIB, and IIIC, respectively, and 96.0%, 87.6%, and 59.3% in L-stage A, B, and C, respectively (p < 0.0001). AICs for TNM and L-stage were 14,795.5 and 14,707.8, respectively.CONCLUSIONS:Prognosis stratification of the stage classification for Stage III colon cancer was superior with L-stage compared to TNM stage classification.
DOI 10.18632/oncotarget.27692
PMID 32913558