KOTERA Yoshihito
   Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine
   Position  
Article types Original article
Language English
Peer review Non peer reviewed
Title Proposal of a novel H category-based classification of colorectal liver metastases based on a Japanese nationwide survey.
Journal Formal name：Journal of hepato-biliary-pancreatic sciences
Abbreviation：J Hepatobiliary Pancreat Sci
ISSN code：18686982/18686974
Domestic / ForeginForegin
Volume, Issue, Page 28(4),pp.317-326
Author and coauthor Beppu Toru, Imai Katsunori, Honda Goro, Sakamoto Katsunori, Kobayashi Shin, Endo Itaru, Hasegawa Kiyoshi, Kotake Kenjiro, Itabashi Michio, Hashiguchi Yojiro, Kotera Yoshihito, Yamaguchi Tatsuro, Tabuchi Ken, Kobayashi Hirotoshi, Yamaguchi Kensei, Morita Satoshi, Kikuchi Ken, Miyazaki Masaru, Sugihara Kenichi, Yamamoto Masakazu, Takahashi Keiichi,
Publication date 2021/04
Summary BACKGROUND:The conventional H category-based classification for colorectal liver metastases (CRLM) was created by equal weighting of tumor number and tumor size; however, our previous nomogram to predict postoperative disease-free survival demonstrated that CRLM ≥5 as a parameter provided 4.5 times greater impact compared with a largest CRLM size >5 cm.METHODS:A total of 3815 patients newly diagnosed with CRLM between 2005 and 2007, including 2220 resectable cases, were investigated. Six groups were created based on largest lesion size (≤ 5 vs >5 cm) and lesion number (1, 2-4, and ≥5).RESULTS:The novel (n) H1, nH2, and nH3 categories were defined as solitary lesions with a size ≤5 cm; lesions other than nH1 or nH3; and ≥5 lesions with any lesion size, respectively. In the resectable cohort, the 5-year cumulative overall survival rates were 64.0%, 53.5%, and 42.6% in the nH1, nH2, and nH3 groups, respectively (P < .001), and no significant differences were observed between the conventional H2 and H3 categories. In the overall cohort, the discrimination ability of the two classifications were comparable.CONCLUSION:The novel H category-based classification might be beneficial in predicting overall survival in patients with CRLM independent of their resectability.
DOI 10.1002/jhbp.920
PMID 33609318